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POIS could be caused by a defect in neurosteroid precursor synthesis.

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In one patient, the POIS symptoms were so severe, that he decided to undergo removal of the testicles, prostate, and seminal vesicles in order to relieve them.

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Postorgasmic illness syndrome

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Hypoparathyroidism Pseudohypoparathyroidism Pseudopseudohypoparathyroidism.

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Description: The allergy hypothesis has been disputed. POIS is prone to being erroneously ascribed to psychological factors such as hypochondriasis or somatic symptom disorder.